Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
GLP-1 Agonists and Diabetes Management Updates
This episode explores the latest research on GLP-1 receptor agonists, including comparative effectiveness studies and their role in diabetes and weight management. We also discuss insulin de-intensification strategies, diabetes as a multisystem disease, and the importance of continuous glucose monitoring.
Bibliography
1. Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.
Authors: Yao H, Zhang A, Li D, et al.
Journal: BMJ (Clinical research ed.), 2024 Jan 29
PMID: 38286487
DOI: 10.1136/bmj-2023-076410
2. Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial.
Authors: Wadden TA, Chao AM, Machineni S, et al.
Journal: Nature medicine, 2023 Nov
PMID: 37840095
DOI: 10.1038/s41591-023-02597-w
3. Thyrotoxicosis in MCT8 deficiency.
Authors: Boelaert K, Bauer A, Cappola AR, et al.
Journal: The Journal of clinical endocrinology and metabolism, 2026 Mar 17
PMID: 41508830
DOI: 10.1210/clinem/dgaf707
4. Diabetes mellitus as a multisystem disease: understanding subtypes, complications, and the link with steatotic liver diseases in humans.
Authors: Giannakogeorgou A, Roden M, Pafili K
Journal: Hormones (Athens, Greece), 2026 Mar
PMID: 40750733
DOI: 10.1007/s42000-025-00701-y
5. Type 1 diabetes.
Authors: DiMeglio LA, Evans-Molina C, Oram RA
Journal: Lancet (London, England), 2018 Jun 16
PMID: 29916386
DOI: 10.1016/S0140-6736(18)31320-5
6. Insulin therapy DE-intensificAtion with iGlarLixi: A phase 4, open-label, parallel-group randomised controlled trial.
Authors: Novodvorský P, Thieme L, Laňková I, et al.
Journal: Diabetes, obesity & metabolism, 2026 Mar
PMID: 41395661
DOI: 10.1111/dom.70362
7. Arginine Vasopressin Deficiency and Oxytocin Deficiency in the Endocrine Clinic.
Authors: Atila C, Refardt J, Christ-Crain M
Journal: The Journal of clinical endocrinology and metabolism, 2026 Mar 17
PMID: 41363127
DOI: 10.1210/clinem/dgaf651
8. Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.
Authors: Yao H, Zhang A, Li D, et al.
Journal: BMJ (Clinical research ed.), 2024 Jan 29
PMID: 38286487
DOI: 10.1136/bmj-2023-076410
9. International Consensus on Use of Continuous Glucose Monitoring.
Authors: Danne T, Nimri R, Battelino T, et al.
Journal: Diabetes care, 2017 Dec
PMID: 29162583
DOI: 10.2337/dc17-1600
10. Metabolic syndrome and peripheral neuropathy.
Authors: Kazamel M, Stino AM, Smith AG
Journal: Muscle & nerve, 2021 Mar
PMID: 33098165
DOI: 10.1002/mus.27086
Authors: Yao H, Zhang A, Li D, et al.
Journal: BMJ (Clinical research ed.), 2024 Jan 29
PMID: 38286487
DOI: 10.1136/bmj-2023-076410
2. Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial.
Authors: Wadden TA, Chao AM, Machineni S, et al.
Journal: Nature medicine, 2023 Nov
PMID: 37840095
DOI: 10.1038/s41591-023-02597-w
3. Thyrotoxicosis in MCT8 deficiency.
Authors: Boelaert K, Bauer A, Cappola AR, et al.
Journal: The Journal of clinical endocrinology and metabolism, 2026 Mar 17
PMID: 41508830
DOI: 10.1210/clinem/dgaf707
4. Diabetes mellitus as a multisystem disease: understanding subtypes, complications, and the link with steatotic liver diseases in humans.
Authors: Giannakogeorgou A, Roden M, Pafili K
Journal: Hormones (Athens, Greece), 2026 Mar
PMID: 40750733
DOI: 10.1007/s42000-025-00701-y
5. Type 1 diabetes.
Authors: DiMeglio LA, Evans-Molina C, Oram RA
Journal: Lancet (London, England), 2018 Jun 16
PMID: 29916386
DOI: 10.1016/S0140-6736(18)31320-5
6. Insulin therapy DE-intensificAtion with iGlarLixi: A phase 4, open-label, parallel-group randomised controlled trial.
Authors: Novodvorský P, Thieme L, Laňková I, et al.
Journal: Diabetes, obesity & metabolism, 2026 Mar
PMID: 41395661
DOI: 10.1111/dom.70362
7. Arginine Vasopressin Deficiency and Oxytocin Deficiency in the Endocrine Clinic.
Authors: Atila C, Refardt J, Christ-Crain M
Journal: The Journal of clinical endocrinology and metabolism, 2026 Mar 17
PMID: 41363127
DOI: 10.1210/clinem/dgaf651
8. Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.
Authors: Yao H, Zhang A, Li D, et al.
Journal: BMJ (Clinical research ed.), 2024 Jan 29
PMID: 38286487
DOI: 10.1136/bmj-2023-076410
9. International Consensus on Use of Continuous Glucose Monitoring.
Authors: Danne T, Nimri R, Battelino T, et al.
Journal: Diabetes care, 2017 Dec
PMID: 29162583
DOI: 10.2337/dc17-1600
10. Metabolic syndrome and peripheral neuropathy.
Authors: Kazamel M, Stino AM, Smith AG
Journal: Muscle & nerve, 2021 Mar
PMID: 33098165
DOI: 10.1002/mus.27086
