Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
Advances in Diabetes Management and Metabolic Health
This week we discuss groundbreaking research on tirzepatide therapy, incretin mechanisms, diabetic nephropathy management, cellular senescence in diabetes, innovative exercise interventions, and metabolic complications in cancer survivors.
Bibliography
1. Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes: The SURPASS-6 Randomized Clinical Trial.
Authors: Rosenstock J, Frías JP, Rodbard HW, et al.
Journal: JAMA, 2023 Nov 7
PMID: 37786396
DOI: 10.1001/jama.2023.20294
2. Late endocrine-metabolic complications in survivors of young adult and adult-onset cancers: comprehensive evaluation and strategies for management. An Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical review.
Authors: Felicetti F, Mazzilli R, Gori S, et al.
Journal: Journal of endocrinological investigation, 2026 Apr
PMID: 41335192
DOI: 10.1007/s40618-025-02764-5
3. Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review.
Authors: Di Lorenzo M, Cacciapuoti N, Lonardo MS, et al.
Journal: Current nutrition reports, 2023 Sep
PMID: 37213054
DOI: 10.1007/s13668-023-00479-8
4. Cellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications.
Authors: Syed AR, Aloti RA, Awad BJ, et al.
Journal: Frontiers in endocrinology, 2026
PMID: 41948554
DOI: 10.3389/fendo.2026.1799261
5. Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists.
Authors: Liu QK
Journal: Frontiers in endocrinology, 2024
PMID: 39114288
DOI: 10.3389/fendo.2024.1431292
6. Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes.
Authors: Trinks N, Gancheva S, Pützer J, et al.
Journal: Cell metabolism, 2026 Apr 7
PMID: 41610852
DOI: 10.1016/j.cmet.2025.12.016
7. Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies.
Authors: Dwivedi S, Sikarwar MS
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2025 Jan
PMID: 39572154
DOI: 10.1055/a-2435-8264
8. Longitudinal ultrasound assessment of jugular venous pressure reliably detects hypervolemia: An observational study in healthy volunteers.
Authors: Vogt K, Widmer D, Kirsch M, et al.
Journal: PloS one, 2026
PMID: 41955188
DOI: 10.1371/journal.pone.0346162
9. Intraductal cryobiopsy via percutaneous cholangioscopy for biliary strictures: a multicenter feasibility study.
Authors: Peveling-Oberhag J, Gerges C, Albert J, et al.
Journal: Endoscopy, 2026 Apr
PMID: 41125091
DOI: 10.1055/a-2728-8013
10. Enhancing Quality of Life in Head and Neck Cancer: A Scoping Review on the Role of Physical Prehabilitation.
Authors: Santagostino AM, Parozzi M, Cangelosi G, et al.
Journal: Cancer medicine, 2026 Apr
PMID: 41891359
DOI: 10.1002/cam4.71743
Authors: Rosenstock J, Frías JP, Rodbard HW, et al.
Journal: JAMA, 2023 Nov 7
PMID: 37786396
DOI: 10.1001/jama.2023.20294
2. Late endocrine-metabolic complications in survivors of young adult and adult-onset cancers: comprehensive evaluation and strategies for management. An Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical review.
Authors: Felicetti F, Mazzilli R, Gori S, et al.
Journal: Journal of endocrinological investigation, 2026 Apr
PMID: 41335192
DOI: 10.1007/s40618-025-02764-5
3. Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review.
Authors: Di Lorenzo M, Cacciapuoti N, Lonardo MS, et al.
Journal: Current nutrition reports, 2023 Sep
PMID: 37213054
DOI: 10.1007/s13668-023-00479-8
4. Cellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications.
Authors: Syed AR, Aloti RA, Awad BJ, et al.
Journal: Frontiers in endocrinology, 2026
PMID: 41948554
DOI: 10.3389/fendo.2026.1799261
5. Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists.
Authors: Liu QK
Journal: Frontiers in endocrinology, 2024
PMID: 39114288
DOI: 10.3389/fendo.2024.1431292
6. Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes.
Authors: Trinks N, Gancheva S, Pützer J, et al.
Journal: Cell metabolism, 2026 Apr 7
PMID: 41610852
DOI: 10.1016/j.cmet.2025.12.016
7. Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies.
Authors: Dwivedi S, Sikarwar MS
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2025 Jan
PMID: 39572154
DOI: 10.1055/a-2435-8264
8. Longitudinal ultrasound assessment of jugular venous pressure reliably detects hypervolemia: An observational study in healthy volunteers.
Authors: Vogt K, Widmer D, Kirsch M, et al.
Journal: PloS one, 2026
PMID: 41955188
DOI: 10.1371/journal.pone.0346162
9. Intraductal cryobiopsy via percutaneous cholangioscopy for biliary strictures: a multicenter feasibility study.
Authors: Peveling-Oberhag J, Gerges C, Albert J, et al.
Journal: Endoscopy, 2026 Apr
PMID: 41125091
DOI: 10.1055/a-2728-8013
10. Enhancing Quality of Life in Head and Neck Cancer: A Scoping Review on the Role of Physical Prehabilitation.
Authors: Santagostino AM, Parozzi M, Cangelosi G, et al.
Journal: Cancer medicine, 2026 Apr
PMID: 41891359
DOI: 10.1002/cam4.71743
