Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Rethinking Gastric Cancer: H. pylori Eradication, Emerging Therapies, and the Role of AI
This week’s episode explores new evidence on H. pylori eradication and gastric cancer prevention, insights from the LEAP-015 trial, the impact of acromegaly on cancer risk, and the promise of AI in biomarker scoring. Plus, we discuss vonoprazan-based regimens, global HIPEC guidelines, and a rare pediatric gastric cancer case that challenges conventional assumptions.
Bibliography
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- Shitara K, Lorenzen S, Li J, et al. Lenvatinib plus pembrolizumab and chemotherapy versus chemotherapy in advanced metastatic gastroesophageal adenocarcinoma (LEAP-015). J Clin Oncol. 2025;43(22):2502-2514. doi:10.1200/JCO-25-00748
- Demarchis L, Chiloiro S, Giampietro A, et al. Cancer screening in patients with acromegaly: a personalized approach and international registries. Rev Endocr Metab Disord. 2025;26(4):525-538. doi:10.1007/s11154-025-09957-6
- Caputo A, Angerilli V, Gambella A, et al. Immunohistochemical biomarker scoring in gastroesophageal cancers: can computers help us? Pathol Res Pract. 2025;272:156068. doi:10.1016/j.prp.2025.156068
- Han RS, Hao JW, Wang T, et al. Triple therapy with vonoprazan for H. pylori eradication: a multicenter RCT. World J Gastroenterol. 2025;31(28):109001. doi:10.3748/wjg.v31.i28.109001
- Tonello M, Cenzi C, Pizzolato E, et al. National guidelines for cytoreductive surgery and HIPEC in peritoneal malignancies. Ann Surg Oncol. 2025;32(8):5795-5806. doi:10.1245/s10434-025-17518-z
- Oliveira M, Barbosa J, Teixeira P. Listeria monocytogenes gut interactions and listeriosis. Microbiol Res. 2025;297:128187. doi:10.1016/j.micres.2025.128187
- Albano F, Severini FL, Calice G, et al. Tumor microenvironment and inflammatory pathways in drug resistance in gastric cancer: systematic review and meta-analysis. BBA Mol Basis Dis. 2025;1871(6):167821. doi:10.1016/j.bbadis.2025.167821
- Ji B, Ma Z, Liu S, et al. Pyroptosis in gastric mucosal injury-related diseases (Review). Int J Mol Med. 2025;56(4):165. doi:10.3892/ijmm.2025.5606
- Li X, Luan X, Yu W, et al. Gastric signet ring cell carcinoma in a H. pylori-positive 10-year-old boy: case report and literature review. Cancer Sci. 2025;116(8):2064-2074. doi:10.1111/cas.70112
