Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Breakthroughs in Gastroenterology and Hepatology Research
This episode covers groundbreaking research in gastroenterology and hepatology, including new treatments for NASH and Crohn's disease, advances in diagnostic methods, and important insights into liver failure management and microbiome research.
Bibliography
1. American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.
Authors: Mekinian A, Georgin-Lavialle S, Ferrada MA, et al.
Journal: Arthritis & rheumatology (Hoboken, N.J.), 2026 Mar
PMID: 40787890
DOI: 10.1002/art.43287
2. Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.
Authors: Harrison SA, Taub R, Neff GW, et al.
Journal: Nature medicine, 2023 Nov
PMID: 37845512
DOI: 10.1038/s41591-023-02603-1
3. What defines a healthy gut microbiome?
Authors: Van Hul M, Cani PD, Petitfils C, et al.
Journal: Gut, 2024 Oct 7
PMID: 39322314
DOI: 10.1136/gutjnl-2024-333378
4. Viral hepatitis: Past, present, and future.
Authors: Odenwald MA, Paul S
Journal: World journal of gastroenterology, 2022 Apr 14
PMID: 35582678
DOI: 10.3748/wjg.v28.i14.1405
5. Calprotectin: from biomarker to biological function.
Authors: Jukic A, Bakiri L, Wagner EF, et al.
Journal: Gut, 2021 Oct
PMID: 34145045
DOI: 10.1136/gutjnl-2021-324855
6. Anti-aging effect of Hedgehog signaling.
Authors: Kim JH, Hwang JY, Jun JH, et al.
Journal: Experimental & molecular medicine, 2026 Mar
PMID: 41673424
DOI: 10.1038/s12276-025-01626-7
7. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Authors: Pennazio M, Rondonotti E, Despott EJ, et al.
Journal: Endoscopy, 2023 Jan
PMID: 36423618
DOI: 10.1055/a-1973-3796
8. Hematopoietic Stem-Cell Gene Therapy for Cystinosis.
Authors: Barshop BA, Ball ED, Benador N, et al.
Journal: The New England journal of medicine, 2026 Feb 19
PMID: 41707137
DOI: 10.1056/NEJMoa2506431
9. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Authors: Lee WM, Hynan LS, Rossaro L, et al.
Journal: Gastroenterology, 2009 Sep
PMID: 19524577
DOI: 10.1053/j.gastro.2009.06.006
10. Efficacy of biological therapies and small molecules in induction and maintenance of remission in luminal Crohn's disease: systematic review and network meta-analysis.
Authors: Barberio B, Gracie DJ, Black CJ, et al.
Journal: Gut, 2023 Feb
PMID: 35907636
DOI: 10.1136/gutjnl-2022-328052
Authors: Mekinian A, Georgin-Lavialle S, Ferrada MA, et al.
Journal: Arthritis & rheumatology (Hoboken, N.J.), 2026 Mar
PMID: 40787890
DOI: 10.1002/art.43287
2. Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial.
Authors: Harrison SA, Taub R, Neff GW, et al.
Journal: Nature medicine, 2023 Nov
PMID: 37845512
DOI: 10.1038/s41591-023-02603-1
3. What defines a healthy gut microbiome?
Authors: Van Hul M, Cani PD, Petitfils C, et al.
Journal: Gut, 2024 Oct 7
PMID: 39322314
DOI: 10.1136/gutjnl-2024-333378
4. Viral hepatitis: Past, present, and future.
Authors: Odenwald MA, Paul S
Journal: World journal of gastroenterology, 2022 Apr 14
PMID: 35582678
DOI: 10.3748/wjg.v28.i14.1405
5. Calprotectin: from biomarker to biological function.
Authors: Jukic A, Bakiri L, Wagner EF, et al.
Journal: Gut, 2021 Oct
PMID: 34145045
DOI: 10.1136/gutjnl-2021-324855
6. Anti-aging effect of Hedgehog signaling.
Authors: Kim JH, Hwang JY, Jun JH, et al.
Journal: Experimental & molecular medicine, 2026 Mar
PMID: 41673424
DOI: 10.1038/s12276-025-01626-7
7. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Authors: Pennazio M, Rondonotti E, Despott EJ, et al.
Journal: Endoscopy, 2023 Jan
PMID: 36423618
DOI: 10.1055/a-1973-3796
8. Hematopoietic Stem-Cell Gene Therapy for Cystinosis.
Authors: Barshop BA, Ball ED, Benador N, et al.
Journal: The New England journal of medicine, 2026 Feb 19
PMID: 41707137
DOI: 10.1056/NEJMoa2506431
9. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Authors: Lee WM, Hynan LS, Rossaro L, et al.
Journal: Gastroenterology, 2009 Sep
PMID: 19524577
DOI: 10.1053/j.gastro.2009.06.006
10. Efficacy of biological therapies and small molecules in induction and maintenance of remission in luminal Crohn's disease: systematic review and network meta-analysis.
Authors: Barberio B, Gracie DJ, Black CJ, et al.
Journal: Gut, 2023 Feb
PMID: 35907636
DOI: 10.1136/gutjnl-2022-328052
