Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Advances in Gastrointestinal Research
This episode explores recent advances in gastrointestinal research, including cholangiocarcinoma biomarkers, HCC treatment resistance mechanisms, and novel approaches to chronic liver disease and IBD management.
Bibliography
1. Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries' framework for digital twin advancement.
Authors: Carpino G, Overi D, Macias RIR, et al.
Journal: Hepatology (Baltimore, Md.), 2026 Apr 1
PMID: 40513068
DOI: 10.1097/HEP.0000000000001425
2. Targeting Tumor-Associated Macrophages and Cancer-Associated Fibroblasts to Overcome Therapeutic Resistance in Hepatocellular Carcinoma.
Authors: Cho HJ, Kwon M, Varner JA
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research, 2026 Apr 1
PMID: 41636792
DOI: 10.1158/1078-0432.CCR-25-2944
3. Preventing First and Further Decompensation in Advanced Chronic Liver Disease.
Authors: Süffert LC, de Faria Moraes B, Cançado GGL
Journal: Liver international : official journal of the International Association for the Study of the Liver, 2026 Apr
PMID: 41773498
DOI: 10.1111/liv.70568
4. Individualising endpoints in chronic HBV treatment: HBsAg loss and beyond.
Authors: Sonneveld MJ, Janssen HLA
Journal: Journal of hepatology, 2026 Apr
PMID: 41397536
DOI: 10.1016/j.jhep.2025.12.006
5. Public Imaging Datasets of Gastrointestinal Endoscopy for Artificial Intelligence: a Review.
Authors: Zhu S, Gao J, Liu L, et al.
Journal: Journal of digital imaging, 2023 Dec
PMID: 37735308
DOI: 10.1007/s10278-023-00844-7
6. Strategies for Colorectal Cancer Screening.
Authors: Ladabaum U, Dominitz JA, Kahi C, et al.
Journal: Gastroenterology, 2020 Jan
PMID: 31394083
DOI: 10.1053/j.gastro.2019.06.043
7. Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease.
Authors: Reinisch W, Rittscher J, Iacucci M, et al.
Journal: Gastroenterology, 2026 Apr
PMID: 41665578
DOI: 10.1053/j.gastro.2025.12.002
8. Tools and advanced imaging technologies for assessing intestinal epithelial barrier integrity: a systematic review.
Authors: Vieujean S, Atreya R, Buda A, et al.
Journal: American journal of physiology. Gastrointestinal and liver physiology, 2026 Apr 1
PMID: 41677575
DOI: 10.1152/ajpgi.00447.2025
9. Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.
Authors: Nambu R, Iwama I, Takeuchi I, et al.
Journal: Journal of gastroenterology, 2026 Apr
PMID: 41483143
DOI: 10.1007/s00535-025-02334-9
10. Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency.
Authors: Nomden M, Kuipers F, Lexmond WS, et al.
Journal: Hepatology (Baltimore, Md.), 2026 Apr 1
PMID: 40644308
DOI: 10.1097/HEP.0000000000001430
Authors: Carpino G, Overi D, Macias RIR, et al.
Journal: Hepatology (Baltimore, Md.), 2026 Apr 1
PMID: 40513068
DOI: 10.1097/HEP.0000000000001425
2. Targeting Tumor-Associated Macrophages and Cancer-Associated Fibroblasts to Overcome Therapeutic Resistance in Hepatocellular Carcinoma.
Authors: Cho HJ, Kwon M, Varner JA
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research, 2026 Apr 1
PMID: 41636792
DOI: 10.1158/1078-0432.CCR-25-2944
3. Preventing First and Further Decompensation in Advanced Chronic Liver Disease.
Authors: Süffert LC, de Faria Moraes B, Cançado GGL
Journal: Liver international : official journal of the International Association for the Study of the Liver, 2026 Apr
PMID: 41773498
DOI: 10.1111/liv.70568
4. Individualising endpoints in chronic HBV treatment: HBsAg loss and beyond.
Authors: Sonneveld MJ, Janssen HLA
Journal: Journal of hepatology, 2026 Apr
PMID: 41397536
DOI: 10.1016/j.jhep.2025.12.006
5. Public Imaging Datasets of Gastrointestinal Endoscopy for Artificial Intelligence: a Review.
Authors: Zhu S, Gao J, Liu L, et al.
Journal: Journal of digital imaging, 2023 Dec
PMID: 37735308
DOI: 10.1007/s10278-023-00844-7
6. Strategies for Colorectal Cancer Screening.
Authors: Ladabaum U, Dominitz JA, Kahi C, et al.
Journal: Gastroenterology, 2020 Jan
PMID: 31394083
DOI: 10.1053/j.gastro.2019.06.043
7. Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease.
Authors: Reinisch W, Rittscher J, Iacucci M, et al.
Journal: Gastroenterology, 2026 Apr
PMID: 41665578
DOI: 10.1053/j.gastro.2025.12.002
8. Tools and advanced imaging technologies for assessing intestinal epithelial barrier integrity: a systematic review.
Authors: Vieujean S, Atreya R, Buda A, et al.
Journal: American journal of physiology. Gastrointestinal and liver physiology, 2026 Apr 1
PMID: 41677575
DOI: 10.1152/ajpgi.00447.2025
9. Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.
Authors: Nambu R, Iwama I, Takeuchi I, et al.
Journal: Journal of gastroenterology, 2026 Apr
PMID: 41483143
DOI: 10.1007/s00535-025-02334-9
10. Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency.
Authors: Nomden M, Kuipers F, Lexmond WS, et al.
Journal: Hepatology (Baltimore, Md.), 2026 Apr 1
PMID: 40644308
DOI: 10.1097/HEP.0000000000001430
